The effect of Indoxacarb on blood parameters and liver tissues in Mice

الملخص

This study was conducted to evaluate the effect of Indoxacarb (Avant), an oxidiazine compound on hematological, some biochemical parameters of liver functions and histological changes in the liver. Sixteen albino adult mice were divided into two groups (n=8). Group1 (control group). Group 2 injected intraperitoneally with 90 mg/kg indoxacarb for a period of two weeks. Hematological investigations revealed a significant decrease in red blood cells count (RBC), haematocrit, mean corpuscular volume (MCV) and hemoglobin content (Hb) compared to the control group, whereas, white blood cells (WBC) and platelets counts a highly significant increase. Biochemical analysis illustrated that indoxacarb caused a marked elevation of alanine amino transferase (ALT) and considerable decrease in the total protein and albumin. Microscopic examination of liver sections illustrated that treatment with 90 mg/kg indoxacarb led to histoarchitectural changes of the liver including focal aggregations of lymphocytes, necrosis, degeneration of hepatocytes, inflammatory cells infiltration in portal tracts, pyknosis, karyolysis and sinusoidal dilatation. These results concluded that short period of exposure to indoxacarb may have toxic effects on public safety.