مجلة تريبوليتانا الطبية

Schiff Bases and their Potential Role in Drug Resistance Cancer Therapy

2025-04-07T15:46:58+00:00

Schiff bases and their metal complexes are increasingly grasping focus as a promising cancer therapy, due to their ability to
exhibit strong cytotoxic effects against various types of cancer cells and minimum effects on non-cancerous cells, therefore,
effectively combating drug resistance. Schiff bases can easily be prepared and modified to form complexes with transition
metals, which presents an exciting opportunity for scientists to develop innovative cancer therapies. Currently many scien
tific researchers are focusing on several Schiff bases, showing their promising applications as anticancer agents. This review
will focus on the mechanisms of cancer drug resistance, the role of Cisplatin as a potent anticancer drug that is often limited
by drug resistance, and the potential of using various Schiff bases in the inhibition of cancer cell proliferation consequently
affecting cancer treatments.

Vitamin C Effect on Dementia Induced by Scopolamine Hbr in Mice (Histological Study)

2025-04-07T15:54:21+00:00

Dementia is a deterioration in cognitive ability, which affects memory, and behavioral and psychological symp
toms. Scopolamine hydrobromide is a muscarinic receptor antagonist that induces memory impairment and oxi
dative stress. Vitamin C is a strong antioxidant agent; its deficiency may be associated with an increased risk
of dementia. This work aims to find out the effect of vitamins C on behavior in dementia induced in mice using
scopolamine hydrobromide. The brain histological effect of vitamin C on dementia induced by scopolamine hy
drobromide in albino mice is studied. Method: Male albino mice were divided into ten groups of six each. Group
1: Administered T80(1%) for one week, Group 2: Administered scopolamine HBr at a dose of 6 mg/kg for one
week, Group 3: Administered vitamin C at a dose of 500mg/kg for one week, Group 4: Administered scopolamine
HBr plus vitamin C for one week, Group 5: Administered scopolamine HBr for one week, followed by vitamin C
administration for another one week, Group 6: administered scopolamine plus Donepezil for one week.
Drugs were administered by intraperitoneal route, at the volume of 5ml/kg body weight. All drugs were freshly
prepared; mice were killed by neck dislocation; the brains were immediately removed, inserted in 10% formalin,
and sent to the histology department, for brain histological study. Results and conclusion: Dementia model in
duced by scopolamine HBr, showed mild mononuclear cellular (lymphocytic) infiltration and aggregation, mild
vascular proliferation, and perivascular edema. In the cerebral cortex, focal gliosis with microglial proliferation
and distributed astrocytes was observed. Some shrunken neurons exhibited eosinophilic cytoplasm and shrinkage
of basophilic nuclei. The hippocampus was unremarkable. Brain histological studies showed oxidative changes
in vitamin C treated group compared to the control; vitamin C may act as a pro-oxidant. The combined treatment
of vitamin C and scopolamine HBr produce more damage to cerebral cortex and hippocampus. The damage was
severe when vitamin C is administered after scopolamine HBr

Knowledge, Attitude and Practice of Libyan Mothers Towards Dehydration and Oral Rehydration Salt

2025-04-07T16:46:16+00:00

The present study was aimed to assess the knowledge, attitude and practice of mothers regarding Oral Rehydration Salt (ORS).
In this cross-sectional descriptive study, a total of 340 Libyan mothers were enrolled by convenience sampling. The study was
conducted in Tripoli city, over a 3-months period, during March-May 2022. Data was gathered by means of semi-structured
questionnaire. The questionnaire asked information about the knowledge of mothers regarding ORS, its availability in the
market, method of preparation, frequency of administration, source of information about ORS and the role of ORS in handling
of diarrhea and dehydration.
Of the total 340 mothers, about 81.2% of respondents were with university education level and 82.05% of mothers belonged
to the middle social class. Only 20% of mothers seemed to have sufficient knowledge pertaining ORS preparation and more
than 75% of participants have adequate knowledge regarding its significance in deal with diarrhea. About 45 % of participated
mothers did not know how to prepare ORS and 53.82 % of mothers did know how to use ORS properly. Information associated
with the accessibility of ORS in the market was found to be accurate among 30.88% of mothers. Most of mothers got information
about ORS from heath care provider and less than 10% of mothers were from their mothers and relatives.
Conclusion: Knowledge, attitude and practice regarding ORS were found to be not fully satisfactory among Libyan women. A
health care education program towards importance of ORS is highly recommended.