Early and Prenatal Use of Antibiotics and Risk Atopic Dermatitis among Pre-School Children

الملخص

Overuse or misuse of antibiotics can lead to the development of antibiotic-resistant bacteria, which can be difficult to
treat and can pose a serious threat to public health. In addition, antibiotic misuse can disrupt the balance of bacteria in
the body, leading to an overgrowth of harmful bacteria or a decrease in beneficial bacteria. This can increase the risk of
secondary infections and other health problems. Human microbiome reconstitution from antibiotic treatment is often slow
and incomplete, and, in some cases, may take years to revert to naive configuration. Many studies suggested a strong
correlation between the use of antibiotics and atopic dermatitis. The explanation may be linked to the microbiota changes
related to antibiotic use, knowing that the microbiota influences the immune response. There is evidence showing that
the early gut microbiota of children who develop atopic dermatitis later in life is different from that of children who do
not develop atopic dermatitis, both in terms of composition, and diversity. This cross-sectional study was performed
at Tripoli Libya and it involved 100 cases of pre-school children and 100 cases of pregnant women, in the period from
January 2023 to Jun 2023 to correlate between early and prenatal use of antibiotics and the risk Atopic Dermatitis. In
addition, to identify any inscrutable variables that may affect such correlations, such as environmental factors, parents’
education level, etc. However, the study concluded that there were significant impacts of early and prenatal use of
antibiotics at pre-school age on the evolving of atopic dermatitis (P <0.05).