Roles

She is one of the graduates of the second batch of the college and obtained a doctorate degree from the University of Manitoba in Canada. She has been a faculty member in the Department of Pharmacology at the College of Pharmacy since 1997. she was involved in many commeetes  foe evaluation of master thesis in faculty of pharmacy, university of Tripoli.

Careers

1997-2000 lecturer

2000-2004 assistant prof

2004-2008 associate prof

2008 until now full prof

Research Interests

-Fatma Naas, Aisha Drah, Hanan Abushwereb and Sliman Gargeet. The effect of the co-administration of enalapril on the pharmacodynamics of hydroxyzine in rabbits 2007. Libyan Journal of Medical Research, National Medical Research Center , Zawia-Libya. 01 vol. 5, p:40-43

        H1-receptor antagonists such as hydroxyzine are commonly used to treat allergic dermatitis. However, it has been found that combination of  H1-receptor antagonists with antihypertensive drug such as enalapril reduced their therapeutic efficacy. This could be explained by the vasodilating effect of this drug. The aim of this study was to investigate the suppression of anti-histaminic activity of hydroxyzine caused by concurrent administration of enalapril with hydroxyzine. The administration of hydroxyzine caused a marked suppression of histamine-induced wheal in rabbits. The co-administration of enalapril with hydroxyzine reduces the  suppressive effect on wheal area caused by administration of hydroxyzine alone. This effect can be attributed to the  histamine-like effect of enalapril, in resemblance to enalapril-associated increase of bronchial reactivity to histamine. However, the anti-histaminic effect of hydroxyzine was reduced in combination with enalapril. These study clearly demonstrates the antagonistic effect of enalapril on anti-allergic activity of hydroxyzine which may has to be considered when H1-receptor antagonists are used in treatment of allergy in patients receiving angiotensin converting enzyme inhibitors.  

Fatma Naas, Aisha Dugani, Rabea Musrati , Aisha Drah, ,  and Sliman Gargeet : The Effect of the Co-administration of Imipramine and Chlorpromazine on the Pharmacodynamics of Hydroxyzine    in Rabbits. 2009, Libyan Journal of Medical Resaerch, National Medical Research center. 9(1):65-67.

H1-receptor antagonists such as hydroxyzine are commonly used to treat allergic dermatitis. However, it has been found that combination of  H1-receptor antagonists with antipsychotic drugs such as chlorpromazine or imipramine enhanced their therapeutic efficacy. This could be explained by the additive anti-histaminic effect of these two drugs.The administration of hydroxyzine caused a marked suppression of histamine-induced wheal in rabbits. The co-administration of chlorpromazine or imipramine with hydroxyzine resulted in a significant increase in the suppression of histamine-induced wheal as compared with hydroxyzine alone. However, the potentiation effect of imipramine was more pronounced than that of chlorpromazine.These results suggest that the enhancing effect of chlorpromazine or imipramine on the anti-histaminic efficacy of hydroxyzine is due to the additive antihistaminic property of these two drugs.

Aisha Dugani, Abdelrazak Auzzi, Fatma Naas and Salah Megwes. Effects of the oil and mucilage from flaxseed (Linum usitatissimum) on gastric lesions induced by ethanol in rats 2008. Libyan J Med.

The anti-ulcer activity of the oil and mucilage obtained from flaxseed was evaluated in the rat model of ethanol-imduced gastric ulcer. our result show that pre-treatment of the rats of flaxseed mucilage significantly reduced the number and length of gastric ulcers induced by ethanol. 

G.Rajakumar, F.Naas, R.L.Johnson, and R.K.Mishra: Down-regulation of Haloperidol-induced striatal dopamine receptors supersensitivity by active analogues of L-prolyl-L-leucyl-glycinamide(PLG). 

Tardive dyskinesia, a clinical syndrome, is one of the major side effects of protracted treatment with neuroleptics in schizophrenic patients. Functional supersensitivity of striatal dopamine receptors is believed to contribute to the pathogenesis of schizophrenia and tardive dyskinesia. In a rodent model of neuroleptic-induced dopamine receptor supersensitivity, we investigated the efficacy of structurally modified analogues of PLG to down-regulate the striatal dopamine receptor supersensitivity as determined by alterations in [3H]spiroperidol binding to striatal membranes in vitro. The PLG analogue, L-prolyl-L-leucyl-(+)-thiazolidine-2-carboxamide-HCl, when given at the dose of 10 mg/kg IP for 5 days prior to haloperidol (3 mg/kg IP 21 days) significantly prevented the up-regulation of striatal dopamine receptor supersensitivity, thus demonstrating a prophylactic effect. Two other analogues, L-prolyl-L-leucyl-5-aminomethyltetrazole and L-prolyl-L-leucyl-glycine-dimethylamide at a dose of 10 mg/kg IP when given concurrently with haloperidol for 21 days, suppressed the development of dopamine receptor supersensitivity. None of the analogues tested in the post-haloperidol session reversed the haloperidol-induced increase in the density of striatal dopamine receptors. Active PLG analogues hold promise as potential therapeutic agents for the amelioration of tardive dyskinesia.

G.Rajakumar, A.N. Singh,  F.Naas, and RK Mishra :L-prolyl-Lleucyl-glycinamide- A new class of peptide class of peptide antihypertensives.

Accumulating evidence suggests that there is an increase in the density (maximum binding sites) of striatal dopamine receptors in the central nervous system of spontaneously hypertensive rats (SHR). A tripeptide of hypothalamic origin, PLG (L-Prolyl-L-Leucyl-Glycinamide) has been found to have modulatory effect on the dopamine receptors in the central nervous system of rats. Two analogues of PLG with cyclic amino-acid residues, L-Prolyl-L-Leucyl-(-)-thiazolidine-2-carboxamide and L-Prolyl-L-Leucyl-(+)-thiazolidine-2-carboxamide, have shown antihypertensive effect at the established phase of hypertension in 16-week old SHRs at a dose of 35 mg/kg per day per 7 days i.p. It was also observed from studies of radioligand [3H]-spiroperidol binding that the laevo-isomer of the PLG analogue has down-regulated the up-regulated dopamine receptors. Our findings confirm the role of central dopaminergic pathways in the pathogenesis of hypertension in SHR.

External Activities

ٌReviewed master thesis in department of pharmacology, faculty of pharmacy university of Tripoli

External examiner for master students in university of Sabha.

Evaluation and review of promotion of some staff members in some universities in Libya.