Prevalence and Clinical Significance of Nasal Colonization with Multi-drug Resistant Bacteria on Libyan Kidney Recipients

Abstract

We investigated the nasal carriage of multi-drug resistant bacteria and their influences on renal function among
Libyan renal transplanted recipients (RTRs). A prospective study of nasal swabs taken from 60 consecutive patients
at the time of follow-up clinic has shown 42 (70%) bacterial carriers and 18 (30%) non-carriers. Of 42 positive
specimens, 14 specimens contain only one type of bacteria and 28 specimens yielded more than one bacterial isolates.
A total of 70 bacterial strains were isolated from 42 nasal swaps where gram positive bacteria represent 60% (42 of
70) and gram negative bacteria represent 40% (28 of 70). The most frequently isolated gram positive organisms were
S. aureous followed by S. epidermitis which both represent the majority of the isolates. Moreover, the most frequently
Gram-negative isolated organisms were Pseudomonas spp, Enterobacter spp, and E. coli. Almost all confirmed
isolates exhibited high resistance rates to Augmentin and trimethoprim/sulfamethoxazole and moderate resistance
rates to Vancomycin, Rifampicin, and Clindamycin. The only effective antibiotics in this study against the isolates
were Imipenem and Ciprofloxacin. The monitoring of renal performance has showed no direct correlation between
bacterial nasal carriage and renal performance among RTRs.