Molecular genetics of β-talassemia in Tripoli-Libya

Abstract

β-talassemia is an inherted blood disorder, in which the body does not make as much as β-globin as it should be.  Hemoglobin is the part of a red blood cells (RBCs) that carries oxygen throughout the body.  β-talassemia includes three main forms, major, intermadia, and minor.  β-globin DNA mutations present in 14 subjects from 866 adult samples.  β-talassemia, major and minor were analyzed by DNA sequencing of amplified DNA.  Different β-talassemia mutations were identified.  The three common three β-talassemia found in Libya were B°CD39 (C→T) N=6, B+IVS-I,6 (C→T) N=5, and B+IVS-1,110 (G→A) N=3.