Schiff Bases and their Potential Role in Drug Resistance Cancer Therapy

الملخص

Schiff bases and their metal complexes are increasingly grasping focus as a promising cancer therapy, due to their ability to
exhibit strong cytotoxic effects against various types of cancer cells and minimum effects on non-cancerous cells, therefore,
effectively combating drug resistance. Schiff bases can easily be prepared and modified to form complexes with transition
metals, which presents an exciting opportunity for scientists to develop innovative cancer therapies. Currently many scien
tific researchers are focusing on several Schiff bases, showing their promising applications as anticancer agents. This review
will focus on the mechanisms of cancer drug resistance, the role of Cisplatin as a potent anticancer drug that is often limited
by drug resistance, and the potential of using various Schiff bases in the inhibition of cancer cell proliferation consequently
affecting cancer treatments.