
أ.د. سهامالأزرق
قسم الأمراض والتشخيص المعملي كلية الطب البيطري
الاسم الكامل
أ.د. سهام العابد حسـن الأزرق
المؤهل العلمي
دكتوراة
الدرجة العلمية
أستاذ
ملخص
أ. د. سهـام العــابد هي احد اعضاء هيئة التدريس بقسم الامراض والتشخيص المعملي بكلية الطب البيطري. تعمل السيدة د. سهـام العــابد بجامعة طرابلس كـاستاذ مساعد منذ 2013-10-05 ولها العديد من المنشورات العلمية في مجال تخصصها. وتم ترقيتها الي درجة أستاذ 7-10-2021م. شغلت منصب رئيس قسم الامراض والتشخيص المعملي في الفترة من 2010 الي 2015، ووكيل للكلية للشوؤن العملية في الفترة من 2013 الي 2016
المؤهلات
دكتوراة
علم امراضجامعة هانوفر / ألمانيا
5 ,2010
المنشورات
Clinical, radiological, and pathological findings of primary nasal osteosarcoma in a Libyan cat
Background: Although bone tumors are common pathologies in companion animals, limited reports describe nasal osteosarcoma (OSA) in cats. Case description: A case of nasal OSA in a local Libyan cat was admitted to the Veterinary Teaching Hospital at the Faculty of Veterinary Medicine, University of Tripoli-Libya, with nasal swelling and discharges and facial deformity. The radiological findings revealed nasal osteolysis with the absence of evidence of lung metastasis. In addition, fungal growth was not identified in microbiological culture. Furthermore, the pathological examination has grossly revealed a destructed nasal bone due to the presence of a tumor mass, with a mucohemorrhagic nasal discharge and absence of metastasis. OSA was confirmed histopathologically. Conclusion: This report presents the clinical, radiological, and pathological findings of a primary nasal OSA in a Libyan cat with no tumor metastasis to other body organs.
Mohamed Hamrouni S. Abushhiwa, Seham AL-Abed Hassan AL-Azreg, ٍٍSamer Khalifa Khalil Tmumen, Abdulrhman Mohamed Salah Alrtib, Abdulkareem Khalifa Ali Elbaz, Mahir Kubba, Al-Asayed R. Al-Attar, Emad M R Bennour(12-2019)
Publisher's website
Mohamed Hamrouni S. Abushhiwa, Seham AL-Abed Hassan AL-Azreg, ٍٍSamer Khalifa Khalil Tmumen, Abdulrhman Mohamed Salah Alrtib, Abdulkareem Khalifa Ali Elbaz, Mahir Kubba, Al-Asayed R. Al-Attar, Emad M R Bennour(12-2019)
Clinical, radiological, and pathological findings of primary nasal osteosarcoma in a Libyan cat
Abstract
Background: Although bone tumors are common pathologies in companion animals, limited reports describe nasal
osteosarcoma (OSA) in cats.
Case description: A case of nasal OSA in a local Libyan cat was admitted to the Veterinary Teaching Hospital at the
Faculty of Veterinary Medicine, University of Tripoli–Libya, with nasal swelling and discharges and facial deformity.
The radiological findings revealed nasal osteolysis with the absence of evidence of lung metastasis. In addition, fungal
growth was not identified in microbiological culture. Furthermore, the pathological examination has grossly revealed
a destructed nasal bone due to the presence of a tumor mass, with a mucohemorrhagic nasal discharge and absence of
metastasis. OSA was confirmed histopathologically.
Conclusion: This report presents the clinical, radiological, and pathological findings of a primary nasal OSA in a
Libyan cat with no tumor metastasis to other body organs.
Keywords: Cat, Nasal cavity, Primary osteosarcoma.
Mohamed Hamrouni S. Abushhiwa, Seham AL-Abed Hassan AL-Azreg, ٍٍSamer Khalifa Khalil Tmumen, Abdulrhman Mohamed Salah Alrtib, Abdulkareem Khalifa Ali Elbaz, Mahir A. Kubba, Al-Asayed R. Al-Attar, Emad M R Bennour(1-2019)
full text
Publisher's website
Mohamed Hamrouni S. Abushhiwa, Seham AL-Abed Hassan AL-Azreg, ٍٍSamer Khalifa Khalil Tmumen, Abdulrhman Mohamed Salah Alrtib, Abdulkareem Khalifa Ali Elbaz, Mahir A. Kubba, Al-Asayed R. Al-Attar, Emad M R Bennour(1-2019)
Comparative histopathology and immunohistochemistry of human and canine mammary tumors
This study aimed at establishing aspects of comparison between canine and human mammary gland tumors. In order to achieve that, 44 specimens of canine mammary tumors and 70 specimens of human breast tumors were examined in order to state points of similarity in morphology, cells of origin, behavior and existence of tissue markers. We found that the ratio of benign to malignant forms was 4.5% to 95.5% in canine samples and 45.7% to 54.3% in human samples. In both species, malignant tumors composed of infiltrating ductal cells were in the forefront despite dissimilarity in nomenclature. Other kinds of lower rate of existence included, invasive micro-papillary carcinoma, mucinous carcinoma and invasive comedo-carcinoma which have displayed similar morphology and terminology in both species. Chondroid and squamous differentiation were found in human and canine specimens. In human samples, fibro-adenoma mounted up to 30 out of 32 benign tumors (93.8%). Her-2 and Ki-67 were detected in the specimens of both species but ER was detected in human specimens only. Our findings suggest a significant degree of resemblance between certain mammary tumor in canine and human. Such findings are in support of employing dogs in research investigation for human mammary tumors.
Seham ALAzreg(7-2018)
Publisher's website
Seham ALAzreg(7-2018)
Cellular and molecular etiology of hepatocyte injury in a murine model of environmentally induced liver abnormality
Exposures to a wide variety of environmental substances are negatively associated with many biological cell systems
both in humans and rodents. Trichloroethane (TCE), a ubiquitous environmental toxicant, is used in large quantities
as a dissolvent, metal degreaser, chemical intermediate, and component of consumer products. This increases the
likelihood of human exposure to these compounds through dermal, inhalation and oral routes. The present in vivo
study was aimed to investigate the possible cellular and molecular etiology of liver abnormality induced by early
exposure to TCE using a murine model. The results showed a significant increase in liver weight. Histopathological
examination revealed a TCE-induced hepatotoxicity which appeared as heavily congested central vein and blood
sinusoids as well as leukocytic infiltration. Mitotic figures and apoptotic changes such as chromatin condensation and
nuclear fragments were also identified. Cell death analysis demonstrates hepatocellular apoptosis was evident in the
treated mice compared to control. TCE was also found to induce oxidative stress as indicated by an increase in the
levels of lipid peroxidation, an oxidative stress marker. There was also a significant decrease in the DNA content of the
hepatocytes of the treated groups compared to control. Agarose gel electrophoresis also provided further biochemical
evidence of apoptosis by showing internucleosomal DNA fragmentation in the liver cells, indicating oxidative stress
as the cause of DNA damage. These results suggest the need for a complete risk assessment of any new chemical prior
to its arrival into the consumer market.
Keywords: Apoptosis, DNA damage, Environmental toxicant, Liver, Oxidative stres
Seham ALAzreg(9-2016)
Publisher's website
Seham ALAzreg(9-2016)
Cutaneous squamous cell carcinoma in the lateral abdominal wall of local Libyan ewes
Gross and histopathological features of surgically excised squamous cell carcinomas (SCC) observed in thirteen local
Libyan ewes were reported. The age of the ewes enrolled in the current study ranged from 2 to 3 years. The cases were
admitted to private veterinary clinics in south-western region of Tripoli, Libya, during the period between July 2014
and October 2015. All lesions were located in the right and left lateral abdominal wall (caudo-ventrally) with a size
range of 8 to 11 cm in diameter. The tumor masses have been removed by surgical excision. The histopathological
examination of surgically excised masses has revealed the characteristic cell nests of SCC showing central keratinization
and hyalinization with presence of apoptotic bodies, fattened keratinocytes, and a heavy interstitial infiltration of
neutrophils and lymphocytes. The follow up of the cases showed no signs of tumor reoccurrence. In conclusion, SCC
in Libyan sheep affects mainly the woolless areas and can be successfully removed by surgical excision
Seham ALAzreg(8-2016)
Publisher's website
Seham ALAzreg(8-2016)
Fertility and Reproductive Outcome in Mice Following Trichloroethane (TCE) Exposure
Exposure to trichloroethane (TCE), an industrial solvent, has been shown to be negatively associated with reproductive performance. The present study was performed to assess the effects of TCE exposure on the reproductive performance and outcome in mice during a critical developmental window of later reproductive life. A group of female mice were injected intraperitoneally twice weekly for three weeks with TCE (100 and 400 μg/kg). Mice were followed up for signs of toxicity and death. Changes in uterine tissues have also been investigated by histopathology. The results showed that TCE exposure has reduced the number of F0 fertile females comparing to controls. Moreover, TCE exposure resulted in a decreased pups number and changed sex ratio in the litter of F0 TCEtreated dams. Histopathological examination revealed a TCEinduced uterine toxicity appeared as a severe endometrial hyperplasia with squamous cell metaplasia and adenomyosis. These results indicate that TCE exposure during a critical reproductive developmental window could affect the fertility and interfere with the reproductive outcome in mice.
Keyword: TCE; fertility; reproductive outcome; uterus; mice.
Seham ALAzreg(1-2016)
Publisher's website
Seham ALAzreg(1-2016)
Chondroblastic Osteosarcoma in a Cat: Case Report
Osteosarcoma is one of the most important bone tumors of human beings and pet animals. It is a rapidly
progressive, early metastasize, osteolytic, highly fatal tumor. It may arise from central medullary osteoblasts,
peripheral periosteal or perichonderal cells, and extra skeletal tissues or may have a pluripotent potential. A Shirazi
Native breed cat was examined for the presence of multilocular lobulated partially encapsulated masses in the
external ear. The excised tissue revealed anaplastic, chondroblast and osteoblast mesenchymal differentiations
associated with hypercellularity, pleomorphism and increase in mitosis, consistent with chondroblastic
osteosarcoma.
Seham ALAzreg(1-2016)
Publisher's website
Seham ALAzreg(1-2016)
Oxidative Stress Mediated Cytotoxicity of Trichloroethane in a Model of Murine Splenic Injury
The present in vivo murine study was aimed to investigate the long-term effect of repeated administration of
low-dose of the environmental toxicant trichloroethane (TCE) over three weeks on the spleen and peripheral blood cells, and the
possible role of oxidative stress in TCE-induced toxicity. The results showed neither adverse clinical signs nor mortality on the
TCE-treated mice. However, significant changes were noticed in the spleen of those animals. Grossly, the spleen of TCE-treated
group was congested and enlarged (splenomegaly). Histpathologically, the splenic tissues of TCE-treated mice showed signs of
toxicity as highly activated germinal centers of the white pulp with minimal apoptotic reaction as well as a prominent
megakarocytosis and infiltration of the red pulp by comparatively increased number of eosinophiIs and mature lymphocytes were
detected. In addition, lymphocyte numbers were decreased in peripheral blood as well as basophils. In contrast, there was an
increase in monocyte numbers in the peripheral circulation. In addition, lipid peroxidation/ malondialdehyde formation, a
biomarker of oxidative stress, was significantly induced by TCE treatment in the sera and spleen of mice, suggesting an overall
increase in oxidative stress. These results provide further support to a role of oxidative stress in TCE-induced cell death, which
could result in an impaired spleen function. This study concludes that attenuation of TCE-induced splenic damage in mice
provides an approach for preventive and/or therapeutic strategies.
Keywords: Environmental Toxicant, Spleen, Toxicity, Oxidative Stress, DNA Damage, Apoptosis, Mice
Seham ALAzreg(1-2016)
Publisher's website
Seham ALAzreg(1-2016)
a Ceruminous gland adenocarcinoma in a domestic Persian-mix cat (Felis catus)ن
A nine years old Persian-mix female cat has been suffering from recurrent bilateral ceruminous gland adenocarcinoma for many years. Masses were first noticed and resected five years ago, but reoccurred later on two more occasions. The animal has usually experienced distressful ear canal problems in association with these masses. The tumor cellular morphology was reviewed, described and discussed. This article is the first in documenting ceruminous gland adenocarcinoma in a Persian-mix cat in Libya.
Keywords: Ceruminous gland adenocarcinoma, Feline ear tumors, Feline tumors, Otitis externa
Seham ALAzreg(5-2018)
Publisher's website
Seham ALAzreg(5-2018)
Endocardiosis and congestive heart failure in a captive ostrich (Struthio camelus)
A seven-year-old blue-necked male ostrich was found dead after a few days of illness. The animal was living in an open yard of 25 square meters along with three other females. They were given concentrate-rich ration with free access to green leaves and water. Autopsy revealed cardiac enlargement due to left ventricular hypertrophy and right ventricular dilatation. The left aterioventricular valves were irregularly thickened and contracted. The lungs were engorged with blood and the liver had nutmeg appearance. The small intestine showed segmental sub-serosal petechial hemorrhages. Histological examination revealed myxomatous degeneration of the left aterioventricular valves, pulmonary congestion and edema, congestion of periacinar hepatic zone and fatty degeneration of outer zones, renal glomerulosclerosis and arteriosclerosis. The affected parts of the small intestine showed villous atrophy with lacteal distention. The venules in the affected intestinal segment were severely dilated while the arterioles had narrow lumen and irregular wall thickening with hyaline deposition. The current article reports an endocardiosis in ostrich and discusses other vascular disorders.
Keywords: Congestive heart failure, Endocardiosis, Myomatous valvular degeneration, Ostrich.
Seham ALAzreg(11-2013)
Publisher's website
Seham ALAzreg(11-2013)