Abstract
Feline injection site sarcoma (FISS) is a subcutaneous tumor were recognized among four cats aged between 5 - 7 years old. This study included four cases, which referred to the Veterinary Teaching Hospital, University of Tripoli from October 2011 to october 2013. All cats had a history of sudden growth of a subcutaneous mass located on the dorsal midline of the nick, just cranial th the shoulders. The diagnosis was confirmed based on characteristic histopathological finding. Grossly the tumor was infiltrative, irregular, lobulated, extensively ulcerated, necrotic with purulent and/or haemorrhagic exudation with different size among the cases. In all cases the microscopic examination revealed infiltratively growing pleomorphic tumor cells and mononuclear cell aggregations with prominent fibroblastic proliferation. The Present investigation show the first report on FISS in different local and imported cats in Libya.