Complicated chronic fractures are common affections in farm animals because of the difficulty of noticing bone fractures, by owners, immediately after their occurrence particularly in large flocks. This report describes the surgical amputation of the left hind limb in an adult, Libyan Doe due to an infected, compound fracture involving the proximal diaphysis of tibia. The decision was made to perform an amputation, because there were an infection and moist gangrene in the distal part of the leg, and to save the animal's life. The amputation was conducted under the effect of local anesthesia only. The Doe was completely recovered and able to walk on three legs few days post surgery
Abdulrhman Mohamed Salah Alrtib, ٍٍSamer Khalifa Khalil Tmumen, Emad M R Bennour, Mohamed Hamrouni S. Abushhiwa, Younes A. Almusrati, Essam B. Alhemali(6-2016)

Background: During development, oligodendrocyte (OL) lineage cells are susceptible to injury, leading to life-long clinical neurodevelopmental decits, which lack effective treatments. Drugs targeting epigenetic modications that inhibit histone deacetylases (HDACs) protect from many clinical neurodegenerative disorders. Aim: This study aimed to investigate the therapeutic potential of histone deacetylase 2/3 (HDAC2/3) inhibitor MI192 on white matter (WM) pathology in a model of neonatal rat brain injury.Methods: Wistar rats (8.5-day-old, n = 32) were used to generate brain tissues. The tissues were cultured and then randomly divided into four groups and treated as following: group I (sham); the tissues were cultured under normoxia, group II (vehicle); DMSO only, group III (injury, INJ); the tissues were exposed to 20 minutes oxygen-glucose deprivation (OGD) insult, and group IV (INJ + MI192); the tissues were subjected to the OGD insult and then treated with the MI192 inhibitor. On culture day 10, the tissues were xed for biochemical and histological examinations. Results: The results showed that inhibition of HDAC2/3 activity alleviated WM pathology. Specically, MI192 treatment signicantly reduced cell death, minimized apoptosis, and mitigates the loss of the MBP+ OLs and their precursors (NG2+ OPCs). Additionally, MI192 decreased the density of reactive microglia (OX−42+). These ndings demonstrate that the inhibition of HDAC2/3 activity post-insult alleviates WM pathology through mechanism(s) including preserving OL lineage cells and suppressing microglial activation. Conclusion: The ndings of this study suggest that HDAC2/3 inhibition is a rational strategy to preserve WM or reverse its pathology upon newborn brain injury. Keywords: Brain injury, Epigenetics, MI192, Microglia, Oligodendrocyte
Mansur Ennuri Shmela, Mohamed A. Al-Griw, Emad M. Bennour(8-2021)

Abstract Background: Although bone tumors are common pathologies in companion animals, limited reports describe nasal osteosarcoma (OSA) in cats. Case description: A case of nasal OSA in a local Libyan cat was admitted to the Veterinary Teaching Hospital at the Faculty of Veterinary Medicine, University of Tripoli–Libya, with nasal swelling and discharges and facial deformity. The radiological findings revealed nasal osteolysis with the absence of evidence of lung metastasis. In addition, fungal growth was not identified in microbiological culture. Furthermore, the pathological examination has grossly revealed a destructed nasal bone due to the presence of a tumor mass, with a mucohemorrhagic nasal discharge and absence of metastasis. OSA was confirmed histopathologically. Conclusion: This report presents the clinical, radiological, and pathological findings of a primary nasal OSA in a Libyan cat with no tumor metastasis to other body organs. Keywords: Cat, Nasal cavity, Primary osteosarcoma.
Mohamed Hamrouni S. Abushhiwa, Seham AL-Abed Hassan AL-Azreg, ٍٍSamer Khalifa Khalil Tmumen, Abdulrhman Mohamed Salah Alrtib, Abdulkareem Khalifa Ali Elbaz, Mahir A. Kubba, Al-Asayed R. Al-Attar, Emad M R Bennour(1-2019)