Abstract
The increasingon the incidenceof drug-resistant pathogens has drawn the attention ofresearcherstowards screening the antimicrobial action of plant-derived compound.This study aimed to determine the antifungal activity of Malva parvifloraextracts, which is widespread and used by the general population in Libya. Extraction was carried out using a cold maceration method by several different polarity solvents (petroleum ether, ethyl acetate, methanol and distilled water). Their total-phenolic and flavonoid content were assessed. The content of total phenolic and flavonoids were found to be the highestin petroleum ether fraction extract (119.558mg GAEg-1) and (227.029mg RU g-1) respectively. The antioxidant activity was estimated using DPPH as free radical scavenging and sugar reducing power. The methanol fraction extract displayed the highest IC50 (50mg/ml). The results indicate that the increase in the percentage of DPPH free radical inhibition is directly proportional with the increase in the extract concentration. Reducing power increased with the increase on extracts concentration. M.parvifloraleave extracts were tested against fungal speciesAspergillus. fumigatusandCandida. albicansusing antifungal susceptibility assay of yeast and filamentous fungi. Extracts had strong antifungal activity against C.albicansand A. fumigates. Petroleum ether fraction extract has the strongest antifungal activity against A. fumigatuswith 94.96% percentage of inhibition. The percentage of inhibition is 96.48% was shown against C.albicansfor aqueous extract.