Abstract
Inflammatory bowel disease (IBD) is a group of inflammatory gastrointestinal diseases (Crohn´s disease and Ulcerative colitis), with remission and relapse periods. IBD arises as a result of inap-propriate immune response and consequently causes inflammation and intestinal ulcers and annoy-ing symptoms such as abdominal pain, diarrhea, bleeding per rectum, weight loss and anemia, also there is an extra- intestinal manifestation as arthritis, mouth ulcers, primary sclerosing cholangitis, cholelithiasis, eye and skin manifestation. The aim of the current study is to describe the clinical and biochemical profile of adult Libyan IBD patients. Two-hundred patients with endoscopic biopsy proven IBD were enrolled in this study which was started in January 2021 to December 2023, all patients were negative for HBsAg, anti HCV, HIV., negative Covid-19 PCR test, normal D-Dimer, normal CRP, normal coagulation profile (PT & INR). From these 200 patients 70 patients (35%) were asymptomatic (in remission) and 130 patients (65%) were symptomatic in which 60 patients (30%) were UC presented with frequently rectal bleeding, diarrhea with mucus, and the others 70 patients (35%) were CD presented with frequent abdominal pain, fever, intestinal obstruction, peri-neal disease, and post-operative recurrence, and both groups associated with high fecal calprotectin. IBD patients' symptoms either UC (bleeding per rectum, diarrhea with mucus) or CD (abdominal pain, fever, perianal disease, intestinal obstruction) with high fecal calprotectin associated with ac-tive disease.