Abstract
ABSTRACT Normal pregnancy is associated with metabolic changes leading to decreased insulin sensitivity and reduced glucose tolerance. However, 3-5% of pregnant women proceed to develop gestational diabetes mellitus (GDM). Researchers elsewhere studied the use of metformin in many fields and the benefit to risk balance of using metformin during pregnancy and the risk of fetotoxic. In this study, the use of Metformin to control Glucose in pregnant women with gestational diabetes mellitus (GDM) was examined and its safety use during the first trimester of pregnancy was evaluated.A group of pregnant patients with gestational diabetes mellitus from the first trimester of pregnancy, non-smoking with no family history of congenital malformation disease, aged between (20-45 years) and have no liver diseases and who had indicating good compliance at more than one visit over several month until delivery put on Metformin were participated in this trial. The results show that all the studied group of pregnant women using metformin 500mg daily delivered healthy babies.Meta-analysis by mother risk program showed no increase in incidence of malformations by use of Metformin during the first trimester of pregnancy.A hundred outpatients were participated in the survey on the general knowledge and awareness of diabetic patients to their illness and medication used their aged between 20-40 years old. It was realized that 90% of physicians are not giving patients full information about their illness and the use of Metformin during pregnancy. Also, about 65% of patients did not know about the nutritionist in the hospital, the right control diet for diabetes, courses on first aid, rapid diagnosis of poisoning and follow the written procedures to dealing with such cases.