Abstract
Abstract: Traditional herbal treatments is used for prevention and/or treatment of urolithiasis with less expense and perhaps fewer side effects. Urolithiasis is considered the most common urinary tract diseases. Raphanus sativus, (Brassicaceae) is consumed throughout the world. Traditionally, the plant has been recommended as an antiurolithic. The present study was undertaken to evaluate its effectiveness as an antiurolithic against expeimentally calcium oxalate induced nephrolithiasis in albino mice. Phytochemical and histopathological analysis were carried out. Raphanussativusseeds extract wasrich in saponins, anthraquinone glycosides, and phenolic compounds; while with limited amount of flavonoids, steroids, and alkaloids. Histological examination of kidney showed that, Raphanus sativus seeds extract has very potent antiurolithiatic activity. Antiurolithiatic effects of Raphnussativusseed extract may be mediated possibly through a combination of calcium oxalate crystal inhibition, antioxidative, diuretic activity, antispasmodic, anti-inflammatory and analgesic properties. Further clinical studies are required to evaluate efficacy and safety of Raphnus sativus seed extract in human beings.