Oral Candida colonization in HIV-infected patients: Species and antifungal susceptibility in Tripoli/Libya

Date

2018-8

Type

Article

Journal title

Heighten Science Publications Corporation

Issue

Vol. 1 No. 1

Author(s)

et al Mohamed H, Krema Z, Mokthar E, Ellabib M, El Magrahi H

Pages

1 - 8

Abstract

Results: Oral Candida colonization is detected in all patients with and without clinical syndromes, and Candida albicans were accounted for (74%), C. dubliniensis (11%) and C. glabrata (6%). A high proportion of Candida species (42%) showed decreased susceptibility to fluconazole. Among C., albicans more than 30% of isolate were resistant to most new azole antifungal including fluconazole, itraconazole, posoconazole and voriconazole. Conclusions: A significant number of oral Candida species particular Candida albicans exhibiting decreased susceptibility to fluconazole were isolated from colonized HIV-infected individual, given the high incidence and severity of fungal infections in HIV-infected individuals. The results of this study reinforce the importance of antifungal susceptibility testing, which contributes to the therapeutic strategies and highlights the need for continuous surveillance of Candida colonization in this population.

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