Abstract
Development of new drugs, especially in the area of oncological and infectious disease represents today one of the most important research fields. The marine environment is a tremendous source of natural products. Many new compounds isolated from marine micro- and macroorganisms showed prominent biological effects, mostly antibiotic and cytotoxic activities. The current study aimed to investigate pure compounds which were isolated from marine-derived fungi. The study was preformed with fractions from two marine derived fungal strains, i.e. Verticillium teneru and Acremonium sp. The isolation of the desired secondary metabolites was carried out using different chromatographic separation techniques (TLC, VLC and mainly HPLC). Chemical and spectroscopic methods (1D NMR, 2D NMR, MS, IR and UV) were applied for structural elucidation of the separation compounds. Extracts of two algal-derived fungus strains with high cytotoxic properties, were investigated chemically. This investigation resulted in the isolation and structure elucidation of three pure compounds representing different structural subclasses, one of them 1 proved to be new natural products and two were known compounds2 & 3.