The Role of Human Leukocyte Antigen Typing in Libyan Patients with Chronic Periodontitis

Date

2015-9

Type

Article

Journal title

Infectious Diseases & Therapy

Issue

Vol. 5 No. 3

Author(s)

Daeki AO and Maroof F

Abstract

AbstractBackground: Periodontitis is an inflammation of gums and teeth bone that caused by certain bacterial normalflora in the mouth leading to destroy periodontal tissues. Human leukocyte antigen (HLA) gene has an important rolein determinant the susceptibility and progression of periodontitis in human to facilitate diagnostic and therapeuticvalue. This study was performed to find out the association between HLA classes I and II genes with chronicperiodontitis.Material and methods: A total of 114 individuals (60 patients with chronic periodontitis and 54 controls) werecollected from Tripoli Central Hospital. All study population was examined clinically using Ramfjord chart fordiagnosis the periodontitis cases and subsequently were analyzed their blood samples using specific-sequenceoligonucleotide PCR (SSO-PCR) assay for typing various HLA loci.Results: Distribution of different HLA-B and HLA-A loci among patients and control individuals were statisticallysignificant in the HLA-B45 and HLA-A30 alleles, P<0.03 and P<0.04, respectively. Furthermore, statisticallysignificant differences were observed between patients and controls in HLA-DRB114 and HLA-DRB5 alleles, P<0.00and P<0.00, respectively. Generally, there is non-significant differences were observed in HLA-DRB3, HLA-DRB4loci.Conclusion: The HLA-B45 and HLA-A30 alleles may represent as risk factors for chronic periodontitis cases inLibyan population, whereas HLA-DRB114 and HLA-DRB5 may indicate to protective factors for chronic periodontitisamong Libyan populations (PDF) The Role of Human Leukocyte Antigen Typing in Libyan Patients with Chronic Periodontitis. Available from: https://www.researchgate.net/publication/322717925_The_Role_of_Human_Leukocyte_Antigen_Typing_in_Libyan_Patients_with_Chronic_Periodontitis [accessed Oct 09 2024].

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