Abstract
Conclusion Non-surgical periodontall therapy significantly improved clinical periodontal parameters and increased Salivary Osteoproteogerin (OPG) Levels among both systematically healthy and controled diabetic patients with chronic periodontitis. A negative correlation between clinical signs of periodontal disease and salivary OPG Concentration was evident suggesting the potential utility of OPG as a biomarker for periodontal disease activity and treatment response. Furthermore, the findings support the rule of diabetes mellitus as a modifying factor that exacerbates periodontal destruction. Therefore, longitudinal studies with larger cohorts are warranted to confirm these findings and to explore the clinical applicability of salivary biomarkers in periodontal diagnostics and management.