Abstract
ABSTRACT Purpose: Omeprazole is one of the most commonly prescribed of protein pump inhibitors (PPIs) drugs which used widely to manage many gastric acid-related conditions such as gastro esophageal disease, gastritis, esophagitis, Barrett’s esophagus, Zollinger-Ellison syndrome, peptic ulcer disease, nonsteroidal anti-inflammatory drug-associated ulcers, and Helicobacter pylori eradication, globally .Aim of study: to evaluate the adverse effects associated with the long-term use of proton pump inhibitors drug( omeprazole). Methodology : a descriptive study for 304 participants were conducted to fill a questionnaire to evaluate the adverse effect of long term use of omeprazole, data were analyzed statistically by SPSSV21. Results: positive correlation between UTI infection and long term use of omeprazole . 66%of people who used omeprazole have deficiency in vitamin D, other side effects are showed in long term use of omeprazole as gastritis , confusion,. Conclusion: because the improper use of omeprazole as a save drug more studies need to evaluate the risk of long term use of omeprazole. Key words: omeprazole, long term use, adverse effect.