Abstract
Exposure to pesticides has harmful impact on human and animal health. Indoxacarb is a relatively new insecticide extensively used in agriculture and veterinary to control pests. The present study was designed to examine the effect of indoxacarb (Avaunt®) on body weight, kidney function and histological changes in female albino mice. The mice were divided into three groups of six animals each. The first group was served as control group received distilled water intraperitoneally, while the other two groups: T1 and T2 were daily intraperitoneal injected with indoxacarb at a dose of 90 and 120 mg/kg body weight respectively for a period of 10 days. Biochemical parameters and histopathological studies were examined. The results of this study showed that indoxacarb induced a considerable increase in the level of creatinine at both doses but there was no significant change in the level of urea at both doses compared to the control. The histopathological study of mice kidney showed that renal corpuscles and associated tubules showed a pronounced damage. The histopathological changes included mild degeneration in the epithelial cells lining renal tubules, atrophy of the corpuscles, necrosis, enlarged and congested renal vein. Therefore, administration of indoxacarb intraperitoneally caused harmful effects in the kidney structure and function of female mice. Hence, indoxacarb could cause dangerous effects particularly at high doses to human and animals. Key words: Indoxacarb, Pesticide, kidney function, histopathology, Mice