Ketene N,S-acetals in heterocyclic synthesis: Part 1: Synthesis of N-phenyl-2-ylidene and 2,5-diylidene-4-thiazolidinone derivatives

Date

2007-7

Type

Article

Journal title

Taylor and francis

Issue

Vol. 28 No. 6

Author(s)

Aysha B. Mezoughi

Pages

563 - 572

Abstract

Ketene N,S-acetal potassium salts, prepared via reaction of active methylenes with phenyl isothiocyanate in the presence of potassium hydroxide, were allowed to react with ethylchloroacetate or chloroacetamide to afford the corresponding 2-ylidene-4-thiazolidinones in good yields. These compounds reacted with a variety of aromatic aldehydes to afford the corresponding 5-arylidene-2-ylidene-4-thiazolidinone derivatives.

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