Abstract
Gold nanoparticles (AuNPs) have received considerable attention recently because of theirchemical properties and potential applications in the medical field.Monodispersed AuNPs in this paper are successfully synthesized by using some stabilized ligandsincluding 3,5-dinitrobenzoic acid (DNBA) and sodium acetate (SA) dispersible in aqueous media,where NaBH4 was used as a reducing agent to reduce KAuCl4 from Au (III) to Au (0).The synthesized AuNPs are characterized by using UV–Vis spectroscopy to evaluate their surfaceplasmon resonance (SPR) absorption in a wavelength range of 500–650 nm. The size and morphologyof AuNPs were determined by transmission electron microscopy (TEM) and dynamic light scattering(DLS), where the results displayed that AuNPs with a strong SPR peak around 530 nm and 536 nmwith an average size of 10 ± 1.2 nm and 14.0 ± 0.9 nm at the initial time for both DNBA-AuNP andSA-AuNP respectively. The synthesized AuNPs illustrate perfect chemical stability for more than 24weeks in an aqueous solution. Therefore, the size of DNBA-AuNP was smaller and most stable thanSA-AuNP, which may be due to 2 nitro groups that have resonance with the benzene ring leading toan increase in the stability of AuNPs.The stability of AuNPs in this work was monitored at a range of pH 2-12. Where high stability wasshowed at pH 6.6 ± 0.5, while the aggregation appears at more than pH 10 and less than pH.3.5.Herein, in this paper AuNPs have shown remarkable results against multi-drug resistancePseudomonas aeruginosa. AuNP functionalized by SA ligand is shown to have a greater biologicaleffect and be more effective than DNBA-AuNP. Due to the high stability of AuNP prepared in thiswork, it can be further tested to be an improved choice for more biomedical applications in the future (1) (PDF) Synthesis of Highly Stabilized AuNPs Using 3,5-Dinitrobenzoic Acid and Sodium Acetate as Capping Agents in an Aqueous Solution and their Bioactivity. Available from: https://www.researchgate.net/publication/355635658_Synthesis_of_Highly_Stabilized_AuNPs_Using_35-Dinitrobenzoic_Acid_and_Sodium_Acetate_as_Capping_Agents_in_an_Aqueous_Solution_and_their_Bioactivity [accessed Feb 21 2023].