Abstract
Background: During early development, environmental compounds can induce adult-onset diseases, and disrupts the circulating vitamin D (VitD) levels. Aim: The aim of this study was to examine the protective role of VitD against the adverse effects of BPA on male and female mice. Methods: A total of 60 male and female Swiss albino mice (3 weeks old) were randomly divided into 5 groups; each consists of 12 mice (6 males and 6 females) and treated as follows: Group I, received no treatment (sham control); Group II, sterile corn oil only (vehicle control); Group III, BPA (400 μg/kg); Group IV, VitD (2195 IU/kg) and Group V, BPA+VitD. At 10.5 weeks old, the animals were sacrificed in order to conduct histological examinations. Results: BPA-exposed mice were found to have neurobehavioral abnormalities, heart, kidney, and lung diseases with increased apoptotic indices in both sexes. On the other hand, treatment of BPA mice with VitD altered this scenario into modulated the motor activity, enhanced the body and organ weights, and preserved the heart, kidney, and lung architecture alongside with decreased percent apoptotic index. Conclusions: Our findings illustrate that VitD protects mice against BPA-induced heart, kidney, and lung abnormalities.