Abstract
Objectives: T-cell immunoglobulin and mucin domain 1 (TIM-1) is a protein that in humans is encoded by the HAVCR1 gene. TIM-1, is a member of the TIM gene family, it is preferentially expressed on Th2 cells and has been identified as a stimulatory molecule for T-cell activation. The relationship between the immune response-related genes and cancer has been demonstrated in a number of studies. This study aimed to investigate possible relationships of TIM-1 gene variant in laryngeal cancer (LC). Materials-Methods: TIM-1 (416G>C) polymorphism was investigated in 219 subjects ( 77 subjects with LC and 142 healthy indeviduals as controls) by using polymerase chain reaction-restriction fragment lenght polymorphism (PCR-RFLP). Results: According to our data, it has been found an increased frequency of CC genotype in laryngeal cancer patients but this difference was not statistically significant (p>0,05). The patients who have distance metastasis (%62,5) have increased GC genotypes than those with no distance metastasis (%37,8) and this value was statisticaly significance (OR:1,652, CI:1,203- 2,267, p= 0,05 ). Moreover; the patients who have node metastasis have increased frequency of G allele (%72,9) than those with absence node metastasis (%54,2) (OR: 1,346, 95% CI: 0,994-1,822). Conclusion: According to our research, TIM-1 (416G>C) polymorphism is associated with the progression but not on the risk of laryngeal cancer in Turkish population, which is the first data for the contribution of the human TIM-1 gene in laryngeal cancer. Our findings regarding the association of TIM-1 (416G>C) polymorphism and clincopathological characteristics should be considered in the further studies with larger sample sizes to assess the impact of TIM-1 gene on disease.