Abstract
ABSTRACT Two extraction steps combined with HPLC with fluorescence detection were developed to determine the toxicokinetics of fumonisin B2 (FB2) in ducks and turkeys. The limit of quantification of the method was 25 ng of FB2/mL. The mean extraction was 63%. After intravenous administration (single dose: 1 mg of FB2/kg of BW), plasma concentration time curves were best described by a 2-compartment open model. In ducks, elimination half-life, mean residence time, and clearance of FB2 were 32 min, 12.9 min, and 9.3 mL/min per kilogram, respectively. In turkeys, these toxicokinetics parameters were 12.4 min, 5 min, and 8.7 mL/min per kilogram, respectively. Only a small amount of FB2 was detected in plasma after oral dosing of 10 mg of FB2/kg of BW.