Abstract
Background: Infection with Helicobacter pylori is typically contracted in early childhood and is associated with a variety of upper gastrointestinal disorders. There is still little local information available on infection epidemiology. This study was performed to determine the antibodies of seroprevalence of H. pylori in people, with their relation to age and gender. Methods: A retrospective epidemiologic survey was conducted in different polyclinics in Tripoli from January 2021 to December 2021 to determine the seroprevalence of H. pylori infection. A total of 707 participants (452 males and 255 females, with mean age of 39 ± 19.3 years) were included in this study. For the detection of H. pylori, enzyme-linked immunosorbent assay kits were utilized. In contrast, the absence of both antibodies (IgG and IgA) resulted in the designation of an H. pylori-negative status. Anti-H pylori immunoglobulin (Ig) G/IgA ≥30 enzyme immune units were classified as H. pylori positive. Chi-square test was used to analyze the obtained data. Results: The overall positive seropositive samples among the study participants were 122 (17.2%). The seropositivity was high 42 (34.4%) among the age group 30 <40 years, compared with the other age groups. There was no significant difference between male and female cases regarding the seropositive samples. Conclusion: Seroprevalence of H. pylori infection shows a drop comparing to previously local reports. Nationwide epidemiological research is necessary for determining the seroprevalence of H. pylori in Libya.