Abstract
A 7-year-old female Labrador retriever was presented for weakness, anorexia, progressive weight loss (cachexia), polyuria and polydipsia. Physical examination revealed jaundice of mucus membranes and sclera, acholic feces, 5% dehydration, hepatomegaly, hepatodynia and sweet fruit smelling from oral cavity.Blood chemistry tests revealed hyperglycemia, hepatic dysfunction, cholestasis and inflammatory leukogram. Hematology revealed absolute neutrophilia with moderate left shift and marked toxic changes in many neutrophils, microcytic hypochromic anemia with some evidence of regeneration. Urinalysis revealed glucosuria, bilirubinuria, proteinuria, ketonuria and isosthenuria. Liver ultrasonography and fine needle aspiration biopsy (FNAB) of the liver were consistent with focal hepatic necrosis. The focal hepatic necrosis was successfully treated. Keywords: diabetes mellitus; hepatic necrosis, management.