Abstract
الوصف Hydroxyurea is an effective treatment for Sickle cell disease. Hydroxyurea has classified as an antineoplastic agent and is also prescribed as Antisickling agent; it works through inhibition of DNA synthesis at S phase. Despite Hydroxyurea benefits sickle cell patients, undesirable side effect such as leukopenia and hyperpigmentation were observed. Hydroxyurea-induced hyperpigmentation is mainly seen in the skin and rarely in the oral cavity. Although Hydroxyrea-induced pigmentation is benign and reversible, this mild pathological condition should have considered