Abstract
Abstract Environmental and/or occupational exposure to toxic substances such as pesticides and heavy metals continues to be a major worldwide public health concern. Epidemiological studies have shown worldwide dramatic increase in cancer, endocrine disruption and male infertility over the past decades. The etiology of these serious health issues are linked to the presence of toxic substances, especially pesticides, in the environment. Assessment of sperm parameters are used as an indicator for identifying and characterizing male reproductive toxic agents. Indoxacarb is a non-organophosphorus oxadiazine insecticide that is considered a safe substitute for organophosphate insecticides. However, there is limited data concerning its reproductive toxicity. Therefore, the aim of this study was to investigate the reproductive toxicity of pesticide Indoxacarb in adult male albino mice and the protective role of Selenium. Forty albino male mice, age 8-12 weeks, were divided into four groups of ten mice each. The mice were treated intraperitoneally (i.p) for 5 consecutive days with: water (5mL/kg) Group I (control), selenium (100 μg/kg) group II, Indoxacarb (90 mg/kg) group III, and combined treatment of Indoxacarb + Selenium group IV. At the end of experiment, seminal fluid was collected from vas