Abstract
AB S T R A C T Moringa oleifera (Lam., L.) and Moringa peregrina (Forssk., F.) are perennial angiosperm plants that are members of the Moringaceae family. The goal of this work was to explore the bioactive properties of M.oleifera and M. peregrina leaves. Antioxidant activity (DPPH) and mineral composition (ICP-MS) were determined. Also, to investigate whether different extracts of M.oleifera and M. peregrine leaveshave an effect on humanbreast cancer cell line MDA-MB-231. The highest antioxidant activities with M. oleifera and M. peregrina extracts were obtained using ethanol and methanol extracts, while the lowest activity was observed with n-hexane. The antioxidant activity increases with increasing concentration of extract. The IC50 value of M. oleifera ethyl acetate extract was 58.25 μg/mL, followed by the ethanol extract 98.21 μg/mL. The IC50 value of M. peregrina methanol extract was 97.14 μg/mL, followed by the ethanol extract 214.38 μg/mL. M. oleifera and M. peregrina leaves were found to be a good supplement of K, Ca and Fe. Ethyl acetate crude extract of M. oleifera exhibited a positive effect on the MDA-MB-468 cell line with IC50 value of 8.49. Moreover, methanol crude extract of M. peregrina presented a positive effect on the MDA-MB-468 cell line with IC50 values of 7.74. Staurosporine “positive control” showed cytotoxicity to breast cell line with IC50 values of 5.001 μg/mL. These results indicate that the M. peregrinamethanol extract has anti-cancer activity that can be used to improve novel drugs for breast cancer treatment.