CH651 : Advanced biochemistry

Department

Academic Program

Type

Compulsory

Credits

Prerequisite

Overview

This course aims to:1) The importance of proteins and their relationship to the human body.2) The relationship of RNA to some human diseases.3) Knowledge of medical applications about the nature of fats.4) Diagnosis of diseases resulting from defects in metabolic processes, especially sugars, nucleic acids, proteins and peptides

Intended learning outcomes

A- Knowledge and understanding:1 - The student's realization of the importance of proteins and their relationship to building living organisms.2 - The student's realization of the importance of biochemical structures.3 - The student employs this knowledge and avoids some diseases resulting from metabolic processes.4 - The student's understanding of the relationship of lipids to chronic diseases resulting from them. B. mental skills1- Employ the acquired information with existing applications in the field of health2- The student compares the difference in the nature of the studied molecules in terms of chemical composition.3- Applying learned principles to understanding and diagnosing some diseases4 - The ability to understand the given information and its relationship to the surrounding environment. T. Practical and professional skills1- Uses the information gained in the field of medical analysis.2 - Notes the importance of the topics studied and their relationship to the medical field.3- Distinguish that the studied information is medical or is it a theoretical process only.4- Uses the information gained in the field of medical analysis. w. General and transferable skills1 - Use the discussion groups to understand the information studied.2 - The ability to display data and information clearly.3 - The ability to prepare lectures and translate them correctly.4- To use information technology to obtain as much information and data as possible.

Teaching and learning methods

• Lecturers

• assignments and Oral presentations  Handout of lecture notes for each topic.

• interactive lectures,

• Self-study

• Practical classes that include brain-storming problem solving questions

Methods of assessments

ملاحظات	تاريخ التقييم )الأسبوع(	النسبة المئوية	وزن التقييم	مدة التقييم	أساليب التقييم	رقم التقييم
عددها 0	8&4	33	30	6	Two test exam	التقييم الأو ل
عددها 0	12	8	8	3	Oral presentation	التقييم الثاني
عددها 3	15	12	12	3	assignments	التقييم الثالث
	18	50	53	4	Final Exam	التقييم النهائي
		%111	111 درجة		المجموع

)Course contents( محتوى المقرر

عدد الاسابيع	مذاكرة مستقلة	مناقشة	تمارين	معمل	محاضرة	عدد الساعات	الموضوع العلمي
1	-	-	-	-	3	3	Introduction to Metabolic pathways and metabolic regulation energy transduction in biological systems
2	-	-	-	-	6	6	Allosteric enzymes: Binding of ligands to proteins -Co-operativity, the Hill equation, equilibrium dialysis technique. Sigmoidal kinetics: The MWC and KNF models. Significance of sigmoidal behaviour. Allosteric enzymes and metabolic regulation. Study of ATCaseas typical allosteric enzyme
2	-	-	-	-	6	6	Coenzymes: The mechanistic role of the following coenzymes in enzyme catalyzed reactions-nicotinamide nucleotides, flavin nucleotides, pyridoxal phosphate, coenzyme A, thiamine pyrophosphate and biotin, Folate coenzymes
2	-	-	-	-	6	6	Proteins: Metabolic Classification of the amino acids, Glucogenic and ketogenic of amino acids, Partial Hydrolysis of Peptides and Proteins, Biosynthesis of amino Acids, Urea cycle. Methionine, Histidine and Tryptophan Metabolism. Disorders of amino acids metabolism.
3	-	-	-	-	9	9	Carbohydrates:Glycolysis; Kreb's cycle, oxidative phosphorylation in (ETC), pentose phosphate pathway(PPP), glycogen synthesis and degradation (glycogenolysis, gluconeogenesis), triose-P and Aspmalate shuttles, fructose and galactose metabolism. Disorders of carbohydrates metabolism
2	-	-	-	-	6	6	Lipids: Lipids and their functions ((Phospholipids, Cholesterol, steroids and bile salts), Lipid biosynthesis, Fats/ Triacylglycerols catabolism, Ketone bodies: Biosynthesis and utilization. Lipoprotein; structure, function (VLDL, IDL, LDL and HDL), lipids storage diseases
2	-	-	-	-	6	6	Nucleic Acids DNA replication, transcription, and repair. Translation of mRNA to make proteins, nucleotide synthesis, Synthesis of purine and pyrimidine nucleotides, purine and pyrimidine catabolism, Disorders of nucleic acid metabolism

Analytical Chemistry Advanced (CH612)
Advanced inorganic chemistry (CH622)
Advanced organic chemistry (CH632)
Advanced Physical Chemistry (CH642)
Advanced biochemistry (CH651)
Quantum chemistry (CH643)
Surface chemistry, Catalysis and Colloids (CH644)
Electrochemistry (CH645)
Physical Properties of Polymers (CH646)
Chemical kinetics and Photochemistry (CH647)
Spectroscopy (CH648)
Technical Writing (TW600)