CH668 : Conjugated Proteins & Immunochemistry

أ.1

Understanding of definition, and composition of conjugated proteins

أ.2

Understanding of the overview of immune system including cells, organs and receptors.

أ.3

learn structure and functions of different classes of immunoglobulins, the genetic basis of antibody diversity and the importance of humoral, cell-mediated and innate immune responses in combating pathogens

أ.4

Get acquainted with the importance of antigen-antibody interaction in disease diagnosis.

ب.1

Explain the biological importance of conjugated proteins

ب.2

Become aware with the variations in the levels of glycoproteins and lipoproteins and their relationship with various diseases.

ب.3

Define of Antigens and antibodies and describe their reactions

ب.4

Explain the principles of tolerance, autoimmunity and the role of immunity in

protection against pathogens

ج.1

Develop understanding of the current concepts related to mechanism of autoimmunity

ج.2

Ability to Identify the causes of immunity disorders

ج.3

Acquire knowledge and skills necessary for the critical analysis of the conjugated proteins and immunology literatures

ج.4

Ability to critically evaluate a problem and resolve to challenge blindly accepted concept

د.1

Writing a research report: This will be important for any career in research

د.2

Communicate ideas and arguments effectively

د.3

Manage time and resources effectively and set priorities

د.4

Perform self-directed learning.

رقم التقييم

أساليب التقييم

مدة التقييم

وزن التقييم

النسبة المئوية

تاريخ التقييم (الأسبوع)

ملاحظات

التقييم الأول

Two test exam

6

30

30

4&8

عددها 2

التقييم الثاني

Oral presentation

0

8

8

12

عددها 2

التقييم الثالث

assignments

0

12

12

15

عددها 3

التقييم النهائي

Final Exam

4

50

50

16

المجموع

100 درجة

100%

الموضوع العلمي

عدد الساعات

محاضرة

معمل

تمارين

مناقشة

مذاكرة مستقلة

عدد الاسابيع

Introduction and definitions: Biochemical significance of Conjugated Proteins (CP) Sugar acids and amino sugars

6

3

-

-

-

3

1

Glycoconjugates-Glycosyltransferases- Homo and Heteropolysaccharides in Glycoproteins

6

3

-

-

-

3

1

Role of GP carbohydrates- GP in Bacterial cell walls- Clinical significance –Blood groups- Inhibitors and Mutants in Exploration of GP carbohydrates

6

3

-

-

-

3

1

Hemaglutinin and Influenza virus-Cellular adhesion Molecules CAMs)-Metalloproteins-Hemoproteins-Nucleoproteins.

6

3

-

-

-

3

1

Immunity: Historical Perspective, Cellular and humoral immunity. Role of immunologically important organs and cells, bone marrow, thymus, spleen and lymphocytes. Formation and functions of T and B Lymphocytes. Helper T-cells and killer T-cells. Macrophages. Complement activation by classical, alternate and MB lectin pathway, biological consequences of complement activation, regulation and complement deficiencies

12

6

-

-

-

6

2

Antigens: Definition, epitopes, haptens, carriers, adjuvants, antigenicity

Antibodies: Definition, types and structure of immunoglobulins (IgG – light chain, heavy chain, hyper variable region, constant domains, Fab and Fc). Effector functions of antibody antigenic determinants on Ig, Ig super family. Monoclonal antibodies production and

applications.

12

6

-

-

-

6

2

Major histocompatibility complex (MHC) genes and products – Polymorphism of MHC genes, role of MHC antigens in immune responses, MHC antigens in transplantation.

12

6

-

-

-

6

2

Antigen–antibody reaction in vitro: Formation of antigen-antibody complex. Application of immunodiffusion, RIA, ELISA

6

3

-

-

-

3

1

Autoimmunity and hypersensitivity: Self-tolerance and possible mechanisms of induction of autoimmunity, Organ specific and systemic autoimmune diseases, Types of hypersensitivity

12

6

-

-

-

6

2

Disorders of immunity: Allergy and AIDS. Structure of HIV, mode of transmission

12

6

-

-

-

6

1