Abstract
ims of study. To investigate the characteristics and outcome of BBC in comparison to unilateral breast cancer. Methods: Retrospective study of BBC patients who were registered in Tripoli medical Center in the period between Jan 2005 and Dec 2012. BBC is considered synchronous if it occurs within 3 months from the first breast cancer BC and metachronous if it occurs after 3 months. Results: 437 breast cancer BC patients registered and included in the study. Their median age was 46 years. 25 (5.7%) patients of them developed BBC. 11 (2.5%) of them were synchronous and 14 (3.2%) were metachronous BC. Median age of those patients who had BBC was 41 years.76% of them were premenopausal. Median time for development of metachronous breast cancer was 22.3 months. Compared to unilateral BC, the BBC group had a younger age (p=.02) They also had a more advanced stage according to TNM classification 56% vs. 37.9% (p=0.038) and had more nega- tive hormone receptor status 66.7% vs. 38% (p=0.007). Overall survival in unilateral BC, synchro- nous BBC and metachronous BBC was 166.8 months, 89 months, 72 months respectively. There was no significant difference in overall survival of patients with unilateral and synchronous BBC p=0.355. However, patients with unilateral BC had better overall survival in comparison to meta- chronous BBC p=0.003 and there was no significant difference between synchronous and metachro- nous BBC p=0.554. Conclusion: Patients with BBC were younger and presented with a more advanced tumor size and were more likely to have Estrogen receptor( ER) and Progesterone receptor (PR) negative r