Abstract
Cadmium chlorideis a well known genotoxicand teratogenic effects in animals and a wide spread environmental pollutant. The genotoxic effect of cadmium chloridewas evaluated in laboratory animals (Swiss albino mice). The frequencies of micronucleiand chromosomal aberrations were analysed in bone marrow in the context of heavy metal (Cadmium chloride). Significant correlations were obtained between cadmium chlorideand frequency of micronuclei,chromosomal aberrations and sperm morphology.The results showed that high doses of CdCl2 caused significant increase in chromosomal aberrations,polychromatic micronuclei and sperm abnormality.Thepresent studies reveal the substantiate role of gene mutation and gene expression as causative of micronuclei, chromosomal aberrations and sperm abnormality.