Abstract
ABSTRACT Graviola, called is annona muricata an evergreen plant of the Annonaceae family, mainly distributed in tropical and subtropical parts of the world. The major bioactive components of graviola is acerogenins, rutin, quercetin, kaempferol which have been shown to have anticancer and anti-arthritis. Rabbits were orally given sublethal dose of graviola (100 mg/kg BW) was given alone. The tested doses were given to rabbits every day for 6 weeks. Results showed that graviola caused a significant (PB/0.05) decrease in the levels of plasma cholesterol, triglyceride (TG) and low density lipoprotein (LDL), while the level of high density lipoprotein (HDL) increased.