The principles, practices, and technologies
applied in the preparation of pharmaceutical dosage forms and drug delivery
systems.
The interrelationships between pharmaceutical
and biopharmaceutical principles, product design, formulation, manufacture,
compounding, and the clinical application of the various dosage forms in
patient care.
The materials, the methods, and the strategies
that are used to design and manufacture drug delivery systems, the different
methods of administration of these systems. understanding and determining the
impact of drug kinetics of these systems
Factors and chemical interactions that affect
drug stability and kinetic stability properties, in addition to various
stability tests for evaluating the stability of pharmaceutical products and
determining the shelf life and expiration date, the most appropriate packaging,
and the optimal storage condition for these systems.
The concept of drug-protein binding and the
complex interactions that may occur between the drug and other substances such
as vitamins, minerals, and other endogenous compounds.
The advantages and disadvantages of these
complexes formation as a result of changing their physicochemical and
therapeutic properties.
content outlines:
Modified– Release Pharmaceutical
Dosage forms (MRPD).
Drug Kinetics.
Stability of pharmaceutical products
Complexation and protein binding.
Intended learning outcomes
Upon completion of the
course, the student will be:
Familiar with
the principles of drug delivery and the applications of these principles to
build drug delivery systems
Familiar with
the materials, methods and strategies that are used for designing and manufacturing
of drug delivery systems along with their administration methods
Familiar with
the factors affecting drug stability, kinetic stability properties, shelf-lifedetermination, stability tests, packaging and storage conditions
Familiar with
the importance of complexes (formation of compounds) and drug-protein binding
in improving the therapeutic quality of drugs, in addition to the methods used
to determine the formation of these compounds.
Teaching and learning methods
Lectures/ laboratory classess/group discussions.
Methods of assessments
The students' knowledge and performance about the studied topics are assessed throughout the study period. These assessment methods include the following quizzes, discussion sessions, oral exams, and written exams (grand total mark 100%)
Mid-term exam =20%
Practical exam =20%
Activites=20%
Final exam =40%
References:
Allen,
L., & Ansel, H. C. (2013). Ansel's pharmaceutical dosage forms and drug
delivery systems. (10th edition): Lippincott Williams &
Wilkins. Philadelphia, USA
Florence,
A. T., & Attwood, D. (2015). Physicochemical principles of pharmacy: In
manufacture, formulation and clinical use. (6th edition):
Pharmaceutical press. UK
Aulton, M. E., &
Taylor, K. (2002). Pharmaceutics-The Science of Dosage Form Design. (2nd
edition): Churchill Livingstone. London, England
