P322PT : Pharmaceutics IV

Department

faculty of Pharmacy

Academic Program

Bachelor in pharmaceutical sciences

Type

Compulsory

Credits

03

Prerequisite

P321PT

Overview

The course introduces pharmacy students to

    • The principles, practices, and technologies applied in the preparation of pharmaceutical dosage forms and drug delivery systems.
    • The interrelationships between pharmaceutical and biopharmaceutical principles, product design, formulation, manufacture, compounding, and the clinical application of the various dosage forms in patient care.
    • The materials, the methods, and the strategies that are used to design and manufacture drug delivery systems, the different methods of administration of these systems. understanding and determining the impact of drug kinetics of these systems
    • Factors and chemical interactions that affect drug stability and kinetic stability properties, in addition to various stability tests for evaluating the stability of pharmaceutical products and determining the shelf life and expiration date, the most appropriate packaging, and the optimal storage condition for these systems.
    • The concept of drug-protein binding and the complex interactions that may occur between the drug and other substances such as vitamins, minerals, and other endogenous compounds.

    • The advantages and disadvantages of these complexes formation as a result of changing their physicochemical and therapeutic properties.

content outlines:

  • Modified– Release Pharmaceutical Dosage forms (MRPD).
  • Drug Kinetics.
  • Stability of pharmaceutical products
  • Complexation and protein binding.

Intended learning outcomes

Upon completion of the course, the student will be:

  • Familiar with the principles of drug delivery and the applications of these principles to build drug delivery systems
  • Familiar with the materials, methods and strategies that are used for designing and manufacturing of drug delivery systems along with their administration methods
  • Familiar with the factors affecting drug stability, kinetic stability properties, shelf-lifedetermination, stability tests, packaging and storage conditions
  • Familiar with the importance of complexes (formation of compounds) and drug-protein binding in improving the therapeutic quality of drugs, in addition to the methods used to determine the formation of these compounds.

Teaching and learning methods

Lectures/ laboratory classess/group discussions.

Methods of assessments

The students' knowledge and performance about the studied topics are assessed throughout the study period. These assessment methods include the following quizzes, discussion sessions, oral exams, and written exams (grand total mark 100%)
  • Mid-term exam =20%
  • Practical exam =20%
  • Activites=20%
  • Final exam =40%

References:

Allen, L., & Ansel, H. C. (2013). Ansel's pharmaceutical dosage forms and drug delivery systems. (10th edition): Lippincott Williams & Wilkins. Philadelphia, USA‏

Florence, A. T., & Attwood, D. (2015). Physicochemical principles of pharmacy: In manufacture, formulation and clinical use. (6th edition): Pharmaceutical press.‏ UK

Aulton, M. E., & Taylor, K. (2002). Pharmaceutics-The Science of Dosage Form Design. (2nd edition): Churchill Livingstone. London, England

Instrumental Analysis (P311T)
Physical Pharmacy I (P221PT)
Introduction to pharmaceutical microbiology (P361PT)
Pharmaceutical microbiology I (P362PT)
Physiology I (P231T)
pharmacognosy (P241PT)
pharmaceutical microbiology II (P461PT)
phytochemistry (P341PT)
Physiology II (P232T)
Pharmaceutics II (P224T)
(P222PT)
Pharmaceutics III (P321PT)
Pharmaceutics IV (P322PT)
Biochemistry II (P372PT)
Medicinal Chemistry 2 (P411T)
Pharmaceutical technology 3 (P452PT)
Therapeutics 1 (P431PT)
Hospital pharmacy 1 (P423PT)
Hospital pharmacy ll (P424PT)
Pharmaceutical Analysis 2 (P512T)
Industrial Pharmacy 1 (P551PT)
Pharmacy Practice I (P521PT)
Bioassay (P531PT)
• Industrial Pharmacy 2 (P552PT)
Clinical Biochemist (P571PT)
Pharmacy practice II (P522PT)