Overview
This course introduces the concepts of dosage forms design in laboratories or manufacturers. As it explains the basic principles of
formulation and pre-formulation process for different dosage forms. It also
includes the identification of physiochemical aspects of ingredients with their
practical application. It will focus on some examples of excipients. The aims
of this course are:
- Understanding the reasons for the need to
design dosage forms as well as the general points that must be considered when
designing dosage forms
- Knowing the concept of dosage forms, the
rationale for the development of a particular dosage form, and the different
types of dosage forms
- Understanding the advantages and disadvantages
of each route of administration
- Knowing liquid dosage forms and their
classifications: single-phase formulations, for example, solutions, and
multi-phase formulations, such as suspensions
- Knowing the forms of pharmaceutical solutions,
their main components, methods of preparation, selection of appropriate
packaging, and appropriate storage conditions
-
knowing the concept of dispersion such as
rheology of suspensions, selection of thickening agents, learning the
DLVO theory that explains the stability of dispersion systems and the types of
interactions between
molecules, and the different tests to evaluate the stability of suspensions.
Intended learning outcomes
Upon completion of the course, the student will be:
- familiar with: the basic concepts related to
the formulation and pre-formulation of pharmaceutical dosage forms and the difference
between active pharmaceutical ingredients and various additive
- familiar with: the different physical and
chemical factors, the materials, and the different methods for designing and
manufacturing these pharmaceutical products.
- familiar with: the different types of
pharmaceutical dosage forms, the various ways of administration, the most
appropriate packaging, the appropriate storage condition, and the factors
affecting the stability of the pharmaceutical products
- familiar with: the liquid dosage forms, their
classifications, their main components, and their methods of preparation.
- familiar with various tests that are used to
evaluate the stability of suspensions.
Teaching and learning methods
Lectures/ lab classes/ group discussions.
Methods of assessments
The students' knowledge and performance
about the studied topics are assessed throughout the study period. These
assessment methods include the following quizzes, oral
exams, and written exams (grand total mark 100%)
- Practical and
oral exams =20%
References:
Aulton, M. E., &
Taylor, K. (2002). Pharmaceutics-The Science of Dosage Form Design.
Churchill Livingstone. London, England.
